Is Vitamin C And Calcium The Same Thing

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Is Vitamin C And Calcium The Same Thing

Consumption or injection of very large doses of vitamin C

3D molecular model of vitamin C

Vitamin C megadosage is a term describing the consumption or injection of vitamin C (ascorbic acid) in doses well beyond the current United States Recommended Dietary Allowance of 90 milligrams per day, and often well beyond the tolerable upper intake level of 2,000 milligrams per day.[1] There is no scientific evidence that vitamin C megadosage helps to cure or prevent cancer, the common cold, or some other medical conditions.[2] [3]

Historical advocates of vitamin C megadosage include Linus Pauling, who won the Nobel Prize in Chemistry in 1954. Pauling argued that because humans lack a functional form of L-gulonolactone oxidase, an enzyme required to make vitamin C that is functional in most other mammals, plants, insects, and other life forms, humans have developed a number of adaptations to cope with the relative deficiency. These adaptations, he argued, ultimately shortened lifespan but could be reversed or mitigated by supplementing humans with the hypothetical amount of vitamin C that would have been produced in the body if the enzyme were working.

Vitamin C megadoses are claimed by alternative medicine advocates including Matthias Rath and Patrick Holford to have preventive and curative effects on diseases such as cancer and AIDS,[4] [5] but the available scientific evidence does not support these claims.[3] Some trials show some effect in combination with other therapies, but this does not imply vitamin C megadoses in themselves have any therapeutic effect.[6]

Background [edit]

Vitamin C is an essential nutrient used in the production of collagen and other biomolecules, and for the prevention of scurvy.[7] It is also an antioxidant, which has led to its endorsement by some researchers as a complementary therapy for improving quality of life.[8] Certain animal species, including the haplorhine primates (which include humans),[9] [10] members of the Caviidae family of rodents (including guinea pigs and capybaras),[11] most species of bats,[12] many passerine birds,[13] and about 96% of fish (the teleosts),[13] cannot synthesize vitamin C internally and must therefore rely on external sources, typically obtained from food.

For humans, the World Health Organization recommends a daily intake of 45 mg/day of vitamin C for healthy adults, and 25–30 mg/day in infants.[14]

Since its discovery, vitamin C has been considered almost a panacea by some,[15] although this led to suspicions of it being overhyped by others.[16] Vitamin C has long been promoted in alternative medicine as a treatment for the common cold, cancer, polio, and various other illnesses. The evidence for these claims is mixed. Since the 1930s, when it first became available in pure form, some physicians have experimented with higher-than-recommended vitamin C consumption or injection.[17] Orthomolecular-based megadose recommendations for vitamin C are based mainly on theoretical speculation and observational studies, such as those published by Fred R. Klenner from the 1940s through the 1970s. There is a strong advocacy movement for very high doses of vitamin C, yet there is an absence of large-scale, formal trials in the 10 to 200+ grams per day range.

The single repeatable side effect of oral megadose vitamin C is a mild laxative effect if the practitioner attempts to consume too much too quickly. In the United States and Canada, a tolerable upper intake level (UL) was set at 2,000 mg/day, citing this mild laxative effect as the reason for establishing the UL.[1] However, the European Food Safety Authority (EFSA) reviewed the safety question in 2006 and reached the conclusion that there was not sufficient evidence to set a UL for vitamin C.[18] The Japan National Institute of Health and Nutrition reviewed the same question in 2010 and also reached the conclusion that there was not sufficient evidence to set a UL.[19]

About 70–90% of vitamin C is absorbed by the body when taken orally at normal levels (30–180 mg daily). Only about 50% is absorbed from daily doses of 1 gram (1,000 mg). Even oral administration of megadoses of 3g every four hours cannot raise blood concentration above 220 micromol/L.[20]

Relative deficiency hypothesis [edit]

Linus Pauling's popular and influential 1986 book How to Live Longer and Feel Better advocated very high doses of vitamin C

Humans and other species that cannot synthesize their own vitamin C carry a mutated and ineffective form of the enzyme L-gulonolactone oxidase, the fourth and last step in the ascorbate-producing machinery. In the anthropoids lineage, this mutation likely occurred 40 to 25 million years ago.[ citation needed ] The three surviving enzymes continue to produce the precursors to vitamin C, but the absence of the fourth enzyme means the process is never completed, and the body ultimately disassembles the precursors.

In the 1960s, the Nobel-Prize-winning chemist Linus Pauling, after contact with Irwin Stone,[21] began actively promoting vitamin C as a means to greatly improve human health and resistance to disease. His book How to Live Longer and Feel Better was a bestseller and advocated taking more than 10 grams per day orally, thus approaching the amounts released by the liver directly into the circulation in other mammals: an adult goat, a typical example of a vitamin C-producing animal, will manufacture more than 13,000 mg of vitamin C per day in normal health and much more when stressed.[ citation needed ]

Matthias Rath is a controversial German physician who worked with and published two articles discussing the possible relationship between lipoprotein and vitamin C with Pauling.[22] [23] He is an active proponent and publicist for high-dose vitamin C. Pauling's and Rath's extended theory states that deaths from scurvy in humans during the Pleistocene, when vitamin C was scarce, selected for individuals who could repair arteries with a layer of cholesterol provided by lipoprotein(a), a lipoprotein found in vitamin C-deficient species.[24]

Stone[25] and Pauling[9] believed that the optimum daily requirement of vitamin C is around 2,300 milligrams for a human requiring 2,500 kcal per day. For comparison, the FDA's recommended daily allowance of vitamin C is only 90 milligrams.[1]

Adverse effects [edit]

Although sometimes considered free of toxicity, there are in fact known side effects from vitamin C intake, and it has been suggested that intravenous injections should require "a medical environment and trained professionals."[26]

For example, a genetic condition that results in inadequate levels of the enzyme glucose-6-phosphate dehydrogenase (G6PD) can cause sufferers to develop hemolytic anemia after using intravenous vitamin C treatment.[27] The G6PD deficiency test is a common laboratory test.

Because oxalic acid is produced during metabolism of vitamin C, hyperoxaluria can be caused by intravenous administration of ascorbic acid.[26] Vitamin C administration may also acidify the urine and could promote the precipitation of kidney stones or drugs in the urine.[26]

Although vitamin C can be well tolerated at doses well above what government organizations recommend, adverse effects can occur at doses above 3 grams per day. The common "threshold" side effect of megadoses is diarrhea. Other possible adverse effects include increased oxalate excretion and kidney stones, increased uric acid excretion, systemic conditioning ("rebound scurvy"), preoxidant effects, iron overload, reduced absorption of vitamin B12 and copper, increased oxygen demand, and acid erosion of the teeth when chewing vitamin C tablets.[1] In addition, one case has been noted of a woman who received a kidney transplant followed by high-dose vitamin C and died soon afterwards as a result of calcium oxalate deposits that destroyed her new kidney. Her doctors concluded that high-dose vitamin C therapy should be avoided in patients with kidney failure.[28]

Overdose [edit]

As discussed previously, vitamin C generally exhibits low toxicity. The LD50 (the dose that will kill 50% of a population) is generally accepted to be 11,900 milligrams (11.9 grams) per kilogram in rat populations.[29] The American Association of Poison Control Centers has reported zero deaths from vitamin C toxicity.[30]

Interactions [edit]

Pharmaceuticals designed to reduce stomach acid, such as the proton-pump inhibitors (PPIs), are among the most widely sold drugs in the world. One PPI, omeprazole (Prilosec), has been found to lower the bioavailability of vitamin C by 12% after 28 days of treatment, independent of dietary intake. The probable mechanism of vitamin C reduction, intragastric pH elevated into alkalinity, would apply to all other PPI drugs, though not necessarily to doses of PPIs low enough to keep the stomach slightly acidic.[31] In another study, 40 mg/day of omeprazole lowered the fasting gastric vitamin C levels from 3.8 to 0.7 µg/mL.[32] Aspirin may also inhibit the absorption of vitamin C.[33] [34]

Regulation [edit]

There are regulations in most countries that limit the claims regarding treatment of disease that can be placed on food and dietary supplement product labels. For example, claims of therapeutic effect with respect to the treatment of any medical condition or disease are prohibited by the United States Food and Drug Administration even if the substance in question has gone through well conducted clinical trials with positive outcomes. Claims are limited to Structure:Function phrasing ("Helps maintain a healthy immune system") and the following notice is mandatory on food and dietary supplement product labels that make these types of health claims: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. [35]

Research [edit]

Cancer [edit]

The use of vitamin C in high doses as a treatment for cancer was promoted by Linus Pauling, based on a 1976 study published with Ewan Cameron which reported intravenous vitamin C significantly increased lifespans of patients with advanced cancer.[36] [2] This trial was criticized by the National Cancer Institute for being designed poorly, and three subsequent trials conducted at the Mayo Clinic could not replicate the results.[2] [37] However, the trials at the Mayo Clinic were conducted with oral doses of ascorbate, not intravenous ascorbate as was done in the original trial, and it has been suggested that this difference is a possible reason for the failure of the Mayo Clinic trials to replicate the original trial results.[38]

Preliminary clinical trials in humans have shown that it is unlikely to be a "miracle pill" for cancer and more research is necessary before any definitive conclusions about efficacy can be reached.[26] A 2010 review of 33 years of research on vitamin C to treat cancer stated "we have to conclude that we still do not know whether Vitamin C has any clinically significant antitumor activity. Nor do we know which histological types of cancers, if any, are susceptible to this agent. Finally, we don't know what the recommended dose of Vitamin C is, if there is indeed such a dose, that can produce an anti-tumor response."[37]

The American Cancer Society has stated, "Although high doses of vitamin C have been suggested as a cancer treatment, the available evidence from clinical trials has not shown any benefit."[2]

Burns [edit]

One clinical trial used high intravenous doses of vitamin C (66 mg/kg/hour for 24 hours, for a total dose of around 110 grams) after severe burn injury,[39] but despite being described as promising, it has not been replicated by independent institutions and thus is not a widely accepted treatment.[40] Based on that study, the American Burn Association (ABA) considers high-dose ascorbic acid an option to be considered for adjuvant therapy in addition to the more accepted standard treatments.[41]

Cardiac effects [edit]

Atrial fibrillation (AF) is a common cardiac rhythm disturbance associated with oxidative stress. Four meta-analyses have concluded that there is strong evidence that consuming 1–2 g/day of vitamin C before and after cardiac operations can decrease the risk of post-operative AF.[42] [43] [44] [45] However, five randomized studies did not find any such benefit in the United States, so that the benefit was restricted to less wealthy countries.[45] [46]

Exercise-induced bronchoconstriction [edit]

Exercise-induced bronchoconstriction (EIB) indicates acute narrowing of the airways as a result of vigorous exercise. EIB seems to be caused by the loss of water caused by increased ventilation, which may lead to the release of mediators such as histamine, prostaglandins, and leukotrienes, all of which cause bronchoconstriction. Vitamin C participates in the metabolism of these mediators and might thereby influence EIB.[47] A meta-analysis showed that 0.5 to 2 g/day of vitamin C before exercise decreased EIB by half.[48]

Endothelial function [edit]

A meta-analysis showed a significant positive effect of vitamin C on endothelial function. Benefit was found of vitamin C in doses ranging from 0.5 to 4 g/day, whereas lower doses from 0.09 to 0.5 g/day were not effective. No effect on endothelial function was seen in healthy volunteers or healthy smokers.[49]

Common cold [edit]

A frequently cited meta-analysis calculated that various doses of vitamin C (daily doses under 0.2 grams were excluded) do not prevent the common cold in the general community, although 0.25 to 1 g/day of vitamin C halved the incidence of colds in people under heavy short-term physical stress.[50] Another meta-analysis calculated that, in children, 1–2 g/day vitamin C shortened the duration of colds by 18%, and in adults 1–4 g/day vitamin C shortened the duration of colds by 8%.[50] There is evidence of linear dose-dependency in the effect of vitamin C on common cold duration up to 6–8 g/day.[51] [ jargon ] As noted above, there is an absence of large-scale, formal trials in the 10 to 200+ grams per day range, so no information is available for these higher dosages. Additionally, the cited studies of larger daily doses of vitamin C do not take into account the fast excretion rate of vitamin C at gram-level doses, which makes it necessary to give the total daily amount in smaller, more frequent doses to maintain higher plasma levels.[52] As of 2014, at least 16 studies had found that vitamin C supplements did not prevent the common cold and had minimal effect at best in shortening cold lengths.[3]

See also [edit]

  • Vitamin C
  • Intravenous ascorbic acid
  • Megavitamin therapy
  • Orthomolecular medicine
  • Uric acid

References [edit]

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  38. ^ The Riordan IVC Protocol for Adjunctive Cancer Care Intravenous Ascorbate as a Chemotherapeutic and Biological Response Modifying Agent
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  43. ^ Polymeropoulos, Evangelos; Bagos, Pantelis; Papadimitriou, Maria; Rizos, Ioannis; Patsouris, Efstratios; Toumpoulis, Ioannis (2016). "Vitamin C for the Prevention of Postoperative Atrial Fibrillation after Cardiac Surgery: A Meta-Analysis". Advanced Pharmaceutical Bulletin. 6 (2): 243–50. doi:10.15171/apb.2016.033. PMC4961983. PMID 27478787.
  44. ^ Hu, Xiaolan; Yuan, Linhui; Wang, Hongtao; Li, Chang; Cai, Junying; Hu, Yanhui; Ma, Changhua (2017). "Efficacy and safety of vitamin C for atrial fibrillation after cardiac surgery: A meta-analysis with trial sequential analysis of randomized controlled trials". International Journal of Surgery. 37: 58–64. doi:10.1016/j.ijsu.2016.12.009. PMID 27956113.
  45. ^ a b Hemilä, Harri; Suonsyrjä, Timo (2017). "Vitamin C for preventing atrial fibrillation in high risk patients: A systematic review and meta-analysis". BMC Cardiovascular Disorders. 17 (1): 49. doi:10.1186/s12872-017-0478-5. PMC5286679. PMID 28143406.
  46. ^ Hemilä, Harri (2017). "Publication bias in meta-analysis of ascorbic acid for postoperative atrial fibrillation". American Journal of Health-System Pharmacy. 74 (6): 372–373. doi:10.2146/ajhp160999. hdl:10138/312602. PMID 28274978.
  47. ^ Hemilä, Harri (2014). "The effect of vitamin C on bronchoconstriction and respiratory symptoms caused by exercise: A review and statistical analysis". Allergy, Asthma & Clinical Immunology. 10 (1): 58. doi:10.1186/1710-1492-10-58. PMC4363347. PMID 25788952.
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  49. ^
  50. ^ a b Hemilä, Harri; Chalker, Elizabeth (2013). "Vitamin C for preventing and treating the common cold". Cochrane Database of Systematic Reviews. 2013 (1): CD000980. doi:10.1002/14651858.CD000980.pub4. PMC1160577. PMID 23440782.
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External links [edit]

  • Quackwatch article critical of megadosing for cold prevention, Charles W. Marshall, Ph.D. Accessed 2016-06-02.

Is Vitamin C And Calcium The Same Thing

Source: https://en.wikipedia.org/wiki/Vitamin_C_megadosage

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Elderberry Vitamin C And Zinc

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Elderberry Vitamin C And Zinc

Vitamin A Facts: Everything You Need to Know

Medically Reviewed by Dr Samantha Miller, MBChB

Photo Courtesy: Dean Mitchell/E+/Getty Images

Vitamin A should be an integral part of every person's diet. It plays vital roles in your body by helping to maintain your vision, skin health and even your immune system's ability to work properly. But it's important to consume the right amount; vitamin A can be harmful when your body gets too much of it. Learn more about vitamin A, including what it does, where to find it and what happens when you get too much of it.

What Does Vitamin A Do?

Vitamin A is actually a group of fat-soluble vitamins like retinol, retinal and retinyl esters, all of which have various health benefits. Vitamin A is particularly important in the maintenance of vision — especially your ability to see in low light. Your body converts this vitamin to retinal, which combines with other molecules to form rhodopsin. This is the protein principally responsible for your eyes' absorption of light. If you're worried about your vision getting worse over time, make sure you get enough vitamin A. It's a good way to strengthen your sight naturally.

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Consuming sufficient amounts of vitamin A can also work wonders for your immune system. Vitamin A promotes the production of white blood cells, particularly T cells, which eliminate viruses and bacteria from your body. Vitamin A also stimulates the production of special T cells called regulatory T cells. These help to reduce the risk of your body attacking its own healthy cells, which is what happens with some autoimmune diseases. Furthermore, vitamin A fortifies the linings of your respiratory, intestinal and urinary tracts, along with your skin and mucous membranes. It also sends additional immune cells there to prevent bacteria from entering your body and causing an infection.

Vitamin A is also involved in the maintenance of healthy skin by helping immature skin cells age properly into mature skin cells. It reduces sebum production, which can be problematic in oily skin. In fact, Isotretinoin is a common prescription-only vitamin A derivative used as a treatment for acne.

Vitamin A can also contribute to improved bone growth, cell division and cell differentiation. It even promotes reproduction and is a healthy supplement for people who are breastfeeding.

Food Sources of Vitamin A

Vitamin A is quite easy to come by naturally. Many of the most basic staples in our diets — meat, eggs, milk and cheese, for example — are excellent sources of vitamin A. Other specific animal sources have high vitamin A levels as well, such as kidney and liver. However, it's important to note that some of these foods have high cholesterol and saturated fat levels, so be sure to keep a healthy balance of these in your diet if you choose to eat them.

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Vitamin A exists as either preformed vitamin A or as provitamin A carotenoids. Preformed vitamin A is found in animal and dairy sources. Provitamin A carotenoids include beta-carotene and alpha-carotene, which your body converts into vitamin A and other derivatives. Beta-carotene is found in foods like carrots, pumpkins, sweet potatoes, cantaloupes, grapefruits, spinach, broccoli and apricots. As a general rule, the more vibrant the color of a fruit or vegetable is, the more beta-carotene it contains. As a bonus, you won't have to worry about the fat or cholesterol content in these foods.

Side Effects of Too Much Vitamin A

Getting the right amount of vitamin A in your diet shouldn't have any negative side effects. However, a vitamin A deficiency can lead to health issues over time. If you don't get enough vitamin A, you could develop vision problems. Plus, your immune system could weaken, leaving you susceptible to infectious diseases.

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Perhaps even more serious are the side effects of consuming too much vitamin A, also known as hypervitaminosis A. Initially, too much vitamin A can cause headaches, dizziness, nausea and even vomiting. Because vitamin A is fat-soluble, it tends to get stored in your liver if you consume too much of it, which can lead to liver problems and even liver failure. There's also evidence that getting excess vitamin A can cause osteoporosis and bone fractures.

In particular, pregnant people must be careful about their intake of vitamin A, as getting too much vitamin A can cause birth defects. Pregnant people shouldn't eat foods that are high in vitamin A, such as pate and fish liver oil. In general, babies and small children are more sensitive to vitamin A overdoses and deficiencies, so it's important to closely monitor their daily vitamin A consumption, too.

Taking Vitamin A: Daily Dosage Recommendations

According to the Institute of Medicine Food and Nutrition Board, most adult men should consume around 900 micrograms (mcg) of vitamin A per day, and women should have around 700mcg per day. The recommended daily intake is lower (750–770mcg per day) in pregnant people and higher (1200–1300mcg per day) for people who are breastfeeding.

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The daily dosage for children varies with age. From 0 to 6 months, infants should have 400mcg per day, after which they should consume 500mcg per day until they reach the age of 1. Children 1 to 3 years of age should get 300mcg per day, while those from 4 to 8 years of age need 400mcg per day. Those from 9 to 13 years old need 600mcg each day. Daily recommendations for children don't change based on gender.

These dosage requirements are general guidelines. Individuals may have differing daily recommendations for vitamin A, depending on their health status and lifestyle. Most people can get a sufficient amount of vitamin A simply by eating a balanced diet. Consult a doctor before taking any vitamin A supplements or changing from the recommended dosage for your age and sex.

In summary, it's important to be aware of the foods that'll give you an adequate supply of vitamin A. Provided you have a balanced diet, you might not need to take vitamin A supplements. Be aware of foods containing high levels of vitamin A, and avoid eating too much of these, particularly during pregnancy.

Resource Links:

https://medlineplus.gov/vitamina.html

https://bnf.nice.org.uk/treatment-summary/vitamins.html

https://www.nhs.uk/conditions/vitamins-and-minerals/vitamin-a/

https://ods.od.nih.gov/factsheets/VitaminA-Consumer/

https://ods.od.nih.gov/factsheets/VitaminA-HealthProfessional/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470929/pdf/nutrients-11-00681.pdf

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Elderberry Vitamin C And Zinc

Source: https://www.symptomfind.com/health/vitamin-a-facts-know?utm_content=params%3Ao%3D740013%26ad%3DdirN%26qo%3DserpIndex

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